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Literature summary for 1.5.1.2 extracted from

  • Xiao, S.; Li, S.; Yuan, Z.; Zhou, L.
    Pyrroline-5-carboxylate reductase 1 (PYCR1) upregulation contributes to gastric cancer progression and indicates poor survival outcome (2020), Ann. Transl. Med., 8, 937 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine PYCR1 expression is upregulated in different gastric cancer cohorts. High PYCR1 protein expression is correlated with advanced tumor stage, aggressive histological type and high Ki-67 index. High PYCR1 expression in gastric cancer tissues is an indicator of poor outcome in gastric cancer patients. In vitro, PYCR1 knockdown markedly attenuates gastric cancer cells growth and promoted apoptosis, while overexpression produces the opposite effects. PI3K/Akt axis is strongly correlated with PYCR1 expression and PIK3CB and AKT1 mRNA expression are positively associated with PYCR1 in gastric cancer tissues. PI3K inhibition significantly reduces PYCR1 mRNA and protein expression. Nutrient stress induced by glucose deprivation also regulates PYCR1 expression Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Homo sapiens 5739
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Organism

Organism UniProt Comment Textmining
Homo sapiens P32322
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Expression

Organism Comment Expression
Homo sapiens PI3K inhibition significantly reduces PYCR1 mRNA and protein expression. Nutrient stress induced by glucose deprivation also regulates PYCR1 expression down